There are popular servers written in Python that allow the execution of WSGI applications as well. Keep in mind though that some of these servers were written for very specific applications and might not work as well for standard WSGI application such as Flask powered ones.
Tornado is an open source version of the scalable, non-blocking web server and tools that power FriendFeed. Because it is non-blocking and uses epoll, it can handle thousands of simultaneous standing connections, which means it is ideal for real-time web services. Integrating this service with Flask is a trivial task:
from tornado.wsgi import WSGIContainer
from tornado.httpserver import HTTPServer
from tornado.ioloop import IOLoop
from yourapplication import app
http_server = HTTPServer(WSGIContainer(app))
http_server.listen(5000)
IOLoop.instance().start()